How does one become a guide in the state of Maine?

Other than the state webpage I do not. However, one of the state guides, Steve Vose, runs a very good blog about his work. If you're looking to get in touch with someone with specific questions, perhaps that'd be a good place to start. His email is provided at the top of the "About" page.

http://www.themaineoutdoorsman.com/

http://www.maine.gov/ifw/licenses_permits/guide.htm

You can go to the state fish and game office. They can give you all the information you need. I'm a sub guide in Nevada and the other way we get on board is to get a list of master guides in your area and find one in the area you want to work and get a job as a sub guide and after so may years you can then apply for your master guide licence. This is how it works in Nevada. I hope it will help. Sub guide work isn't to bad of a deal as Your Master guide has to pickup all the permits, insurance and land owner agreements. About all you have to do is Hunt Hunt Hunt. Don't plain on getting rich but you'll have Fun.

Based upon a recent experience with a class of college students, the first requirement would be to be able to find the state on a map of the country.