Posted on Nov 29, 2018
300 Million Letters of DNA Are Missing From the Human Genome
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Posted 6 y ago
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It's a good piece, certainly, quite detailed...however, the components of a genome aren't letters, as is stereotypically phrased, they're complex or hypercomplex valued numbers, implemented molecularly as chemical topological graphs...that being said, I'm by no means surprised, as I'm quite well aware of how microarray approaches give rise to so called SNPs of genomic content, that need to be arranged using a technique called De Bruijn graphs...genomic content is software, no different than human devised software, merely in an as yet unknown computing architectural format...I've researched the topic a long, long time, combed through literally thousands of papers...genomic content arises due to quantum chemistry, giving rise to a reprise of particle physics, which is the true basis of genomics...the so called genetic codes, note, not code, of which there are presently some 31+ or so variants, depending on species, are, in fact, complex valued Hadamard matrices, as has been illustrated in numerous papers I've found, and which result I'd anticipated finding...further, there is considerable addl matl illustrating the quite clear relation between the so called genetic codes, which are, in fact, no more than computational data structures, and string theory, based on Lie supersymmetry algebras...protein folding, is nothing more than based on the Gray code from errors correcting coding theory, closely aligned with Reed Muller error correcting codes as well, which has been shown, in multiple papers, to be directly due to supergravity genomics...that is the true basis of quantitative biology...however, as I'd said, it was certainly a good piece, I'm by no means surprised that such a level of genomic content was unintentionally omitted...when the approach of generating thousands of SNPs using microarrays was developed to accelerate sequencing, I knew it wouldn't be complete, I knew it'd be only an initial approximation toward creating a complete genomic representation, that much was clearly apparent...minimalist organisms, using only a minimum number of genes for cellular viability, as designed organisms, actually interest me far more...then, too, the whole topic of nuclear DNA, actually grossly oversimplifies the entire topic, as it totally ignores mitochondrial or chloroplast DNA, as well as completely ignores microbial genomics...if one examines viral capsid shape, one sees papers immediately that such viral capsid's are based on group theory, which is quite evident in the study of bsvteriophages, viruses infecting bacteria, and which have long been thought, esp now, to be adapted as antibiotics...I've also wondered whether phages also exist for fungi...actually, fungal diseases can actually be considerably nastier quite often, than bacterial versions...the paper did make me think of such various topics, that I'd run across over the course of quite protracted study...however, one would be quite remiss to not consider the work of Gregor Mendel, whose work in genetics of peas, along with the !such later work on jumping genes by a female Nobel winner a few years ago, I can't recall her name at the moment, are actually quite foundational in genetic study...look up the topic of epigenetics as well, it's grown considerably of late in importance in trying to fully comprehend genomic function, as well....
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Wow, crazy info!
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