NFL side the Baltimore Ravens say the United States must tackle racism "head-on" and have promised to use their platform to "drive change now".
In a powerful statement on social media, the Ravens called for those responsible for the shooting of Jacob Blake to be brought to justice.
Blake, a black man, was shot and injured by police on Sunday in Wisconsin, near Milwaukee.
"This is bigger than sports," the Ravens statement said.
"Racism is embedded in the fabric of our nation's foundation and is a blemish on our country's history."
The statement also highlighted the killing of Breonna Taylor, an African-American woman shot during a drugs investigation in March.
Several NFL sides cancelled practice on Thursday, while sports across the US boycotted matches in protest at Blake's shooting.