Posted on Nov 3, 2023
Pulling an all-nighter is a temporary antidepressant : Short Wave
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https://www.npr.org/2023/11/03/ [login to see] /no-sleep-depression-mice-dopamine-antidepressant
What your parents didn't tell you about pulling an all-nighter? It might just ease depression for several days. At least, that's what researchers found happened to mice in a study published in the journal Neuron Thursday.
Most people who've stayed up all night know the "tired and wired" feeling they get the next day. The body might be exhausted, but the brain feels jittery, hyperactive or even giddy. Even after these changes wear off, sleep loss can have a strong antidepressant effect in people that lasts several days.
But researchers hadn't figured out why sleeplessness might have this effect —until this study from neurobiologists at Northwestern University.
What your parents didn't tell you about pulling an all-nighter? It might just ease depression for several days. At least, that's what researchers found happened to mice in a study published in the journal Neuron Thursday.
Most people who've stayed up all night know the "tired and wired" feeling they get the next day. The body might be exhausted, but the brain feels jittery, hyperactive or even giddy. Even after these changes wear off, sleep loss can have a strong antidepressant effect in people that lasts several days.
But researchers hadn't figured out why sleeplessness might have this effect —until this study from neurobiologists at Northwestern University.
Pulling an all-nighter is a temporary antidepressant : Short Wave
Posted from npr.org
Depression
Mental Health
Northwestern University
Research
Posted 7 mo ago
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PO1 William "Chip" Nagel good day Brother William, always informational and of the most interesting. Thanks for sharing, have a blessed day!
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PO1 William "Chip" Nagel
..."Neuroplasticity and sleep loss
Researchers think that transitions between affects — like a depressed state and a non-depressed state — are mediated by neuroplasticity, or the brain's ability to reorganize connections and structures.
Based on their findings in the prefrontal cortex, Kozorovitskiy and her team looked at individual neurons in this area for signs of growth or neuroplasticity. They saw evidence of the early stages of new connections, suggesting that dopamine had rewired neurons in the mice brains to maintain their mood for several days.
Kozorovitskiy says this work may help scientists understand how human moods transition naturally and why some drugs like ketamine have fast-acting effects on mood.
At the same time, scientists have known that chronic sleep loss in humans leads to health problems, so the researchers do not recommend that people start staying up all night to ease depression."
..."Neuroplasticity and sleep loss
Researchers think that transitions between affects — like a depressed state and a non-depressed state — are mediated by neuroplasticity, or the brain's ability to reorganize connections and structures.
Based on their findings in the prefrontal cortex, Kozorovitskiy and her team looked at individual neurons in this area for signs of growth or neuroplasticity. They saw evidence of the early stages of new connections, suggesting that dopamine had rewired neurons in the mice brains to maintain their mood for several days.
Kozorovitskiy says this work may help scientists understand how human moods transition naturally and why some drugs like ketamine have fast-acting effects on mood.
At the same time, scientists have known that chronic sleep loss in humans leads to health problems, so the researchers do not recommend that people start staying up all night to ease depression."
(6)
(0)
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