Will my pregnant wife be able to separate from the Reserves to spend full time at home because of COVID and personal reasons?

It would probably be easier to transfer to the IRR for a spell. Either way, she will need to speak to Retention and Command.

In the regular Army you can ask to be separated for hardship. I assume it is the same in the Reserves. However, these requests are *very* rarely granted, and the onus is on the service member to demonstrate sufficient hardship. I completely understand you not wanting to discuss your (or her) "personal reasons" on an open forum. But without knowing those it is very hard for us to give you valid advice. And she will DEFINITELY have to share those with her CoC if she wants them to be factored into the decision.

(Not trying to pry, here, honestly, just giving you the lay of the land).

Probably not, but it’s possible to go into the IRR for a bit. She would have to go through her command.