On August 17-18, 1969, Hurricane Camille struck the US coastline and killed 259 people (mainly in Alabama, Mississippi, Louisiana). From the article:
"Hurricane Camille was the second-most intense tropical cyclone to strike the United States on record. The most intense storm of the 1969 Atlantic hurricane season, Camille formed as a tropical depression on August 14 south of Cuba from a long-tracked tropical wave. Located in a favorable environment for strengthening, the storm quickly intensified into a Category 2 hurricane before striking the western part of the nation on August 15. Emerging into the Gulf of Mexico, Camille underwent another period of rapid intensification and became a Category 5 hurricane the next day as it moved northward towards the Louisiana–Mississippi region. Despite weakening slightly on August 17, the hurricane quickly re-intensified back to a Category 5 before it made landfall in Pass Christian, Mississippi early on August 18 with a pressure of 900 mbar (26.58 inHg). This was the second-lowest pressure recorded for a U.S. landfall; only the 1935 Labor Day hurricane had a lower pressure at landfall. As Camille pushed inland, it quickly weakened and was a tropical depression by the time it was over the Ohio Valley. Once it emerged offshore, it was able to restrengthen to a strong tropical storm, before it became extratropical, being absorbed by a cold front over the North Atlantic on August 22."