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Originally designed to treat diabetes, semaglutide has garnered significant attention in recent years for its use in weight loss treatments. The drug mimics a hormone naturally produced in the gut after meals and can trigger a number of similar responses that effectively trick the body into thinking it is full.
As of early 2025, the drug is sold under the trade names Ozempic (injection) and Rybelsus (oral) for diabetes and the name Wegovy (injections) for weight loss. All three are made by the Danish firm Novo Nordisk, though a number of similar drugs are in development.
How Does Semaglutide Work?
Semaglutide is in a class of drugs called GLP-1 agonists, which mimic the hormone GLP-1. Humans produce GLP-1 when they eat, and the hormone causes the body to produce insulin—hence its use to treat diabetes
However, GLP-1 also activates receptors in the nervous system, the stomach, and the gut. Each receptor triggers a different response, including slowing the passage of food through the digestive system and prompting the brain to send signals of fullness.
As of early 2025, the drug is sold under the trade names Ozempic (injection) and Rybelsus (oral) for diabetes and the name Wegovy (injections) for weight loss. All three are made by the Danish firm Novo Nordisk, though a number of similar drugs are in development.
How Does Semaglutide Work?
Semaglutide is in a class of drugs called GLP-1 agonists, which mimic the hormone GLP-1. Humans produce GLP-1 when they eat, and the hormone causes the body to produce insulin—hence its use to treat diabetes
However, GLP-1 also activates receptors in the nervous system, the stomach, and the gut. Each receptor triggers a different response, including slowing the passage of food through the digestive system and prompting the brain to send signals of fullness.
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Posted 10 mo ago
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Do you know the story of how this whole line of treatment was discovered? It has to do with the Gila Monster of the Southwest USA and how a certain scientist was investigating how it was that this elusive creature managed to go long periods of time without feeding, and yet maintain their metabolism - and specifically, blood sugar. And that led to understanding GLP-1s. The kind of research that is done on government grants at universities or through the NIH. The same kind of obscure and seemingly "wasteful" medical/scientific research now being imperiled by the Trump Administration. Just one of those "wacky looking" proposals on paper that some might even label "fraud"... except they'd be wrong. Because science is always neat and tidy, or logistical. Sometimes, it's sloppy. And this kind of research starts out to answer one question, and suddenly it leads to an unexpected breakthrough wrt a disease or a chronic condition or an improvement in human quality of life that could not be anticipated or wasn't even on the radar scope when it began.
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