On April 21, 1526, at the first Battle of Panipat, the Central Asian conqueror Babur defeated Sultan Ibrahim Lodi establishing the Mughal Empire in India. The first battle of Panipat was the first time artillery was used in battle in India. Babur was an interesting individual who was reportedly descended from Tamerlane on his father's side and Genghis Khan on his mother's side. Here is a short description from the article on Babur's victory.
"First Battle of Panipat
Five years after his initial invitation to the subcontinent, Babur finally launched an all-out assault on the Delhi Sultanate and Ibrahim Lodi in April 1526. On the plains of Punjab, Babur's army of 24,000—mostly cavalry—rode out against Sultan Ibrahim, who had 100,000 men and 1,000 war elephants. Although Babur appeared to be terribly outmatched, he had something that Lodi did not—guns.
The battle that followed, now known as the First Battle of Panipat, marked the fall of the Delhi Sultanate. With superior tactics and firepower, Babur crushed Lodi's army, killing the sultan and 20,000 of his men. Lodi's fall signaled the beginning of the Mughal Empire (also known as the Timurid Empire) in India."