On September 21, 1558, Charles V, King of Spain (1516-56) and Holy Roman Emperor (1519-56), died of malaria at the age of 58. From the article:
"Emperor Charles V - his life and times
On his 30th birthday Charles was crowned Holy Roman Emperor by Pope Clement VII in Bologna. Less than three years earlier his troops had brutally sacked Rome and Clement had been forced to pay a ransom for his freedom. This is one of the many apparent contradictions in the life of Emperor Charles V (see the pages in 'Charles V'), who ruled much of Europe - the Low Countries, Spain, the Holy Roman Empire, and much of Italy - for almost 40 years in the 16th century. Born in 1500 he was a key figure in the time of the Renaissance and the Reformation (see the pages in 'Charles' World'), in the dynastic struggles between the Habsburgs and the Valois, in efforts to hold back Ottoman expansion from the east, and in the conquest of the Americas. This was a period of increasingly rapid political, social, economic, religious and scientific change – to the great excitement of some and to the horror of others. Charles met with those whose names resound through history - Luther, Erasmus, Henry VIII, Titian, Medici popes and the conquistadores Cortes and Pizarro.
Yet Charles rarely receives the attention that is lavished upon many of his contemporaries. His influence was so widespread that it has been difficult for any one nation to take him to their hearts. He is often remembered for his unprepossessing jaw, as a religious bigot and (in England) as the father of Philip II who sent the Armada. This does not do justice to the man or the ruler. He became the most travelled monarch of his day (see the pages in 'In Charles' Footsteps'), took his responsibilities seriously, was a good judge of character, could inspire loyalty in his family and ministers, and then choose to give up most of his power in his mid-50’s.
There have been many different interpretations of Charles’ life and policies. Each nation, each era, has its own perspective. Was he a lover of peace or an aggressor, a religious zealot or seeker of reconciliation, national hero or destroyer of nations’ hopes, an initiator of grand schemes or one who merely reacted to events? The life of Emperor Charles V provides an insight into the 16th century world. It also has the essential quality which brings history alive – an individual who by chance of birth held great power but who had the usual human virtues and frailties. Few rulers had received such a rich inheritance but few had to deal with so many problems.