On May 26, 1637, the Mystic Massacre took place. In the first battle of the Pequot War in Connecticut, about 500 Pequot Native Americans were killed by Colonial forces. From the article:
"Pequot massacres begin
During the Pequot War, an allied Puritan and Mohegan force under English Captain John Mason attacks a Pequot village in Connecticut, burning or massacring some 500 Indian women, men, and children.
As the Puritans of Massachusetts Bay spread further into Connecticut, they came into increasing conflict with the Pequots, a war-like tribe centered on the Thames River in southeastern Connecticut. By the spring of 1637, 13 English colonists and traders had been killed by the Pequot, and Massachusetts Bay Governor John Endecott organized a large military force to punish the Indians. On April 23, 200 Pequot warriors responded defiantly to the colonial mobilization by attacking a Connecticut settlement, killing six men and three women and taking two girls away.
On May 26, 1637, two hours before dawn, the Puritans and their Indian allies marched on the Pequot village at Mystic, slaughtering all but a handful of its inhabitants. On June 5, Captain Mason attacked another Pequot village, this one near present-day Stonington, and again the Indian inhabitants were defeated and massacred. On July 28, a third attack and massacre occurred near present-day Fairfield, and the Pequot War came to an end. Most of the surviving Pequot were sold into slavery, though a handful escaped to join other southern New England tribes."