Is it possible to obtain top security clearance with your foreign parents/spouse?

You don't need your TS to apply to 35L. Noone on here can tell you if you'll be accepted to 35L, it's an application MOS. So get onto the IKN recruiting site and ask a 35L Recruiter, the only person who can answer your questions and stop your packet. Before you say, "I'm doing research" you're not because Noone on here is the subject matter expert so anything anyone says here is speculation. I've put about a dozen CI agents into the field. You need to ask this stuff to the CI Recruiter and the CI Propenent

The rules change often, but seeing as none of them are from countries of concern, I don't forsee a problem. Depending on the current rules, your wife may need to get a U.S. citizenship, but not necessarily.

It's possible but this is something you will need to work through with your S-2/G-2 offices to get done correctly. Nobody here will be able to give better information than them.