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SGT Unit Supply Specialist
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PO1 William "Chip" Nagel
"Back then, it was a painstaking process. Liquid was usually taken from an open smallpox sore, dried and mixed with water when ready to vaccinate. But transportation delays would sometimes render the vaccine ineffective (the method had a shelf life of weeks to months — not a long time considering the transport options at the time).

On Jan. 1, 1900, a young cow is tied onto a table waiting for the extraction of pox sore to be used for vaccines for smallpox.
Berliner Illustrations Gesellschaft/ullstein bild via Getty Images
The solution? Medical teams would take children (in one case, orphans were used to transport the virus from Spain to its colonies) and animals (like cows and horses) from village to village or from country to country, harvesting liquid from smallpox or cowpox sores and getting it under the skin of an unvaccinated person. But that was clearly not a sustainable practice, says Bhattacharya, for ethical and scientific reasons.

Many years of innovation later followed, including the development of freeze-dried vaccines. The COVID vaccine world is currently dependent on cold chain technology that uses super freezers to keep vaccines at temperatures as low as -13 degrees Fahrenheit while they make their way on planes, trains and automobiles.
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