Dengue fever cases have been cut by 77% in a "groundbreaking" trial that manipulates the mosquitoes that spread it, say scientists.
They used mosquitoes infected with "miraculous" bacteria that reduce the insect's ability to spread dengue.
The trial took place in Yogyakarta city, Indonesia, and is being expanded in the hope of eradicating the virus.
The World Mosquito Programme team says it could be a solution to a virus that has gone around the world.
Few people had heard of dengue 50 years ago, but it has been a relentless slow-burning pandemic and cases have increased dramatically.
In 1970, only nine countries had faced severe dengue outbreaks, now there are up to 400 million infections a year.
Dengue is commonly known as "break-bone fever" because it causes severe pain in muscles and bones and explosive outbreaks can overwhelm hospitals.