Getting To Know The Fungus Among Us (In Our Guts)

Your gut microbiome is composed of more than bacteria—a less populous, but still important, resident is fungi. Many people’s lower digestive tract is home to the yeast Candida albicans, the species implicated in vaginal yeast infections and oral thrush. But new research published in the scientific journal Nature this month suggests that Candida in the gut may also be related to severe cases of inflammatory bowel disease, or IBD.

Candida comes in multiple forms: a single-celled, rounded yeast, and a multicellular, branched version, known as the hyphal form. The latter is capable of invading other cells, and is associated with tissue damage, like that of IBD. The research team writes that our immune system reacts to candida by targeting a protein found on that second, invasive state. Conversely, our bodies seem to leave the rounded, yeast form alone.

Better understanding what drives these distinct responses may provide clues to developing a vaccine that could help people with candida-linked health problems. And postdoctoral researcher Kyla Ost tells guest host Roxanne Khamsi that the relationship appears to be mutualistic—that is, the fungi themselves benefit from being managed in this way.

She explains the nuanced relationship she and her colleagues uncovered, and how uncovering more about gut fungi may bring new insights into the relationship between our microbial communities and our health.