Posted on Nov 27, 2021
Transplants minus a lifelong regimen of anti-rejection drugs? It's becoming a reality at UCLA...
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With traditional transplants, the body recognizes the new organ as a foreign invader, prompting the immune system to attack. A regimen of immunosuppressive anti-rejection drugs tamps down this natural response. The drugs, which themselves carry potentially significant risks, remain necessary throughout the patient’s life because the body continues to see the organ as foreign.
Teaching the body to tolerate transplanted organs
The tolerance approach calls for blending the donor’s and recipient’s immune systems through an infusion of the organ donor’s stem cells shortly after the organ transplant. Called “mixed chimerism,” this blending prompts the recipient’s body to recognize, rather than reject, the new organ.
Teaching the body to tolerate transplanted organs
The tolerance approach calls for blending the donor’s and recipient’s immune systems through an infusion of the organ donor’s stem cells shortly after the organ transplant. Called “mixed chimerism,” this blending prompts the recipient’s body to recognize, rather than reject, the new organ.
Transplants minus a lifelong regimen of anti-rejection drugs? It's becoming a reality at UCLA...
Posted from connect.uclahealth.org
Science
Medicine
Posted >1 y ago
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This would be great if they get to a point where transplant recipients don't need life long medicine to live. It's a great step forward this along with artificial kidney being worked on.
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Is it true that the anti-inflamatory Predizone given to transplant patients can cause Osteoperosis? I took it when I had pneumonia in Iraq and I felt like I could stay awake for days. I had to force myself to sleep.
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LTC John Shaw
Osteoporosis is listed in the General side effects.
https://www.medicinenet.com/prednisone/article.htm
https://www.medicinenet.com/prednisone/article.htm
Prednisone Side Effects, Dosage, Uses & Withdrawal Symptoms
Prednisone (Prednisone Intensol, Rayos) is a drug used for suppressing the immune system and inflammation such as asthma, severe psoriasis, lupus, ulcerative colitis, Crohn's disease, and several types of arthritis. Side effects, drug interactions, dosage, and pregnancy and breastfeeding safety information are provided.
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SFC (Join to see)
I don't know what predizone is. But my daughter and other transplant recipients take prednisone after transplant. She was down to a very low dose of it and then her team stopped it 2 years ago I think. Now she's only on Tacrolimus (Prograf), Mycophenolate (Cellcept) and very small dose of Vit D. That's a lot better than where she was pre transplant and even up to a year post. From post to a year later she was on about 6-7 meds. Pre transplant I can't remember. Too many for an infant, toddler and young child.
She never had any adverse reactions to the prednisone (or any of her meds) but she also had a very small dose of it once they tapered it down. Monthly labs since a year post. She's four years post.
I'm hoping by the time she needs another kidney, hopefully into her 20s or later, all these things are common practice. Either this or the artificial kidney. I don't want her to be on dialysis ever again. I don't think she remembers the first time on it from 2-3 years old.
She never had any adverse reactions to the prednisone (or any of her meds) but she also had a very small dose of it once they tapered it down. Monthly labs since a year post. She's four years post.
I'm hoping by the time she needs another kidney, hopefully into her 20s or later, all these things are common practice. Either this or the artificial kidney. I don't want her to be on dialysis ever again. I don't think she remembers the first time on it from 2-3 years old.
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