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PO1 William "Chip" Nagel
..."Downsides and unknowns
A recent study by the Guttmacher Institute found that 98% of medication abortions in the U.S. used the two-drug protocol in 2020.

But internationally, the second drug, misoprostol, has been used alone for decades, says Dr. Jamila Perritt, president and CEO of Physicians for Reproductive Health. Perritt says the case could leave both healthcare providers and patients facing complex medical and legal decisions about how to move forward without mifepristone.

"At this point, there are still a lot of unknowns in terms of how this is going to play out," Perritt says. "What we do know is that misoprostol has been used on its own for decades around the world and is effective at ending an early pregnancy."

The World Health Organization says misoprostol can be used effectively alone, often with additional doses.

There are downsides, though, including a higher risk of side effects like nausea and cramping, says Dr. Ushma Upadhyay, a public health professor at the University of California, San Francisco, who is researching the misoprostol-only protocol.

"It's so important that patients understand how long they'll be bleeding after they take the miso alone," she says. "And it is longer."...
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