Protesters in Kentucky are on hunger strike demanding justice for Breonna Taylor, a black woman killed by police in her home in March.
The strike comes as thousands of US workers walk off the job on Monday to protest racism, inequality and police brutality.
The Strike for Black Lives builds the country-wide protests over the death of a black man, George Floyd, in May.
Many of the striking workers are considered "essential" in the pandemic.
Organisers said tens of thousands of workers in at least 25 cities were predicted to protest for at least part of the work day on Monday.
Those unable to leave the job for the entire day are instead holding lunchtime rallies and kneeling for eight minutes and 46 seconds - the time that Minneapolis prosecutors initially said that ex-Officer Derek Chauvin knelt on Floyd's neck, allegedly killing him.