https://www.npr.org/sections/goatsandsoda/2023/02/23/ [login to see] /jimmy-carter-took-on-the-awful-guinea-worm-when-no-one-else-would-and-he-triumph
Jimmy Carter took great pride in pointing out that the United States didn't start any new wars during his term as president. But after he left office he launched a war against "neglected" diseases — diseases in far-off lands that most Americans will never suffer from and may not have even heard of. Diseases like lymphatic filariasis, trachoma, river blindness, schistosomiasis ... and a nasty little bug called Guinea worm disease.
Guinea worms are spread through contaminated drinking water and eating undercooked fish. The female worms, which can be up to 3 feet long once they mature, cause incredibly painful, open blisters usually on the infected person's lower legs and feet – through which the worms emerge. It can take a toll for weeks or months, and sometimes permanently, leaving the individual unable to support a family.
And if someone with Guinea worm has contact with water – perhaps to cool the burning pain caused by the worm's emergence – the worm will release tens of thousands of baby worms, contaminating the whole body of water.