In 1959 Barbero assisted the United States Post Office Department, predecessor of what in 1971 became today's United States Postal Service (USPS), in its search for faster, more efficient forms of mail transportation. The Post Office tried its first and only delivery of "Missile Mail", though the idea of delivering mail by rocket was not new. Shortly before noon on 8 June 1959, off the northern Florida coast under command of her new skipper Robert H. Blount, Barbero fired a Regulus cruise missile towards the Naval Auxiliary Air Station, Mayport, Florida. Twenty-two minutes later the training type missile landed at its target; its training-type warhead having been configured to contain two official USPS mail containers.
http://about.usps.com/who-we-are/postal-history/missile-mail.pdf