For those that do not know Pepe's Origin
In 2005, artist Matt Furie created the comic series Boy's Club, which stars the teenage monster characters Pepe, Brett, Andy and Landwolf.
In early 2008, comic in which Pepe pulls his pants down to his ankles in order to urinate is rumored to have been popularized on 4chan's /b/, (random) board, along with the expression "Feels good man."
Katy Perry's Tweet
On November 8th, 2014, Katy Perry tweeted a picture of Pepe crying with the caption "Australian jet lag got me like". Over the next three years, the tweet received more than 17,000 likes and 10,500 retweets.
Nicki Minaj's Instagram Post
On December 18th, 2014, rapper Nicki Minaj posted an illustration of Pepe bent over and prominently displaying his buttocks with the caption "Me on Instagram for the next few weeks trying to get my followers back up". Over the next two years, the post received more than 281,000 likes and 13,900 comments.
Donald Trump's Tweet
On October 13th, 2015, Donald Trump tweeted an illustration of Pepe as himself standing at a podium with the President of the United States Seal. Within 16 months, the post gathered upwards of 11,000 likes and 8,100 retweets.