Posted on Dec 23, 2024
Researchers Find 13 Proteins in the Blood That Are Seemingly Linked to Brain Aging
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In a paper published this month in Nature Aging, a team of scientists analyzed almost 11,000 magnetic resonance imaging (MRI) brain scans from people ages 45 to 82 that were included in the U.K. Biobank. They used artificial intelligence to determine the “brain age” of the scans based on features including brain volume and surface area—essentially, they predicted how old a person is based on their brain data. This “brain age” number can be different from the chronological age of the individual and can shed light on cognitive aging and risk for neurodegenerative diseases.
“The higher the A.I.-predicted age is relative to their actual age, the faster their brain is aging,” explains study lead author Wei-Shi Liu, a neurologist at Fudan University in Shanghai, to New Scientist’s Carissa Wong. Next, researchers appraised the concentration of 3,000 proteins in the participants’ blood, to determine which proteins—delivered to the brain via blood vessels—were associated with brain age. They concluded that 13 proteins—eight linked to fast brain aging, and five linked to slow aging—appeared connected to the brain age. Certain proteins that affect cellular stress and inflammation increased with age, while others that help with maintenance tasks like cell regeneration dwindled, reports Live Science’s Emily Cooke.
“The higher the A.I.-predicted age is relative to their actual age, the faster their brain is aging,” explains study lead author Wei-Shi Liu, a neurologist at Fudan University in Shanghai, to New Scientist’s Carissa Wong. Next, researchers appraised the concentration of 3,000 proteins in the participants’ blood, to determine which proteins—delivered to the brain via blood vessels—were associated with brain age. They concluded that 13 proteins—eight linked to fast brain aging, and five linked to slow aging—appeared connected to the brain age. Certain proteins that affect cellular stress and inflammation increased with age, while others that help with maintenance tasks like cell regeneration dwindled, reports Live Science’s Emily Cooke.
Researchers Find 13 Proteins in the Blood That Are Seemingly Linked to Brain Aging
Posted from smithsonianmag.com
Science
Wellness
Health
Medical
Posted 12 mo ago
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Important research. We have had dementia in our family for a couple generations. One member of our family is 59 and in his 5th year of FTD
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SPC Jeff Daley, PhD
It's an insidious disease. Progress is being made in the search for effective treatments for dementia, particularly Alzheimer's disease, with several promising developments in drug therapies and ongoing research.
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I've been following some retired m.d.s on YouTube who are doing metabolic research and changing over to being functional/interactive/whole health/researchers (in private practice) who share in their videos what they wish they could have done to treat patients when they were part of the insurance run health care system. It's an education, to say the least.
There is a commonality of research data that demonstrates toxic pollutants - all found in the environment and in food - do more to age the brain and body than anything else other than intentional damage to the health.
Where is the wisdom in not dealing with all that at the foundation in current family practice? I find none, for the most part even though organizations of both physicians and patients advocate for a functional holistic system of health care.
I will leave it at that however there is much more that needs to be said in discussion, nationwide.
There is a commonality of research data that demonstrates toxic pollutants - all found in the environment and in food - do more to age the brain and body than anything else other than intentional damage to the health.
Where is the wisdom in not dealing with all that at the foundation in current family practice? I find none, for the most part even though organizations of both physicians and patients advocate for a functional holistic system of health care.
I will leave it at that however there is much more that needs to be said in discussion, nationwide.
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