I am a 100% disabled retired veteran. Does the VA have a program or consideration for a veteran with no family or friends?

Often times your local Veterans Affairs (VA) Centers have programs (called "Medical Companion Program") or know of volunteers who can provide companionship and assistance to veterans for appointments. This varies by center, so call the main number and request to speak to the patient advocate.

As PO1 H Gene Lawrence said, there are many VSOs that do "peer support" with veterans that require someone to accompany them. For example, the "Volunteers for Veterans" program with the DAV connects veterans up with volunteers. Don't forget to check with your local Red Cross office as well.

Check with your local community centers, senior centers, or churches as well. This isn't unique to veterans having surgeries and often have programs that you might be eligible for.

Also, contact your State's Veterans Affairs Office and (depending on how old you are) your state's Office for Aging Services to see if there are any state specific programs.

Finally, you can do a search for programs near you. Some key terms you would use are:
Companion Service for Medical Appointments
Assisted Transportation Services with Companion Care
Medical Escort programs

Bottom line is that most (all?) programs are local, so what would work for someone in Northern Virginia isn't going to work for someone in Eastern Kentucky.

Same problem here. I freaked during the pandemic when many of us were forced out by high rents or landlords selling their rentals. I was literally homeless for a year after I exhausted trips going to motels that cost too much and didn't afford a decent nights sleep. Was having weird symptoms in my legs and was kicked out of the Ears because they thought I was just trying to get a warm bed. Finally got an MRI that revealed multilevel problems and finally got into the Domiciliary. Had to have surgery in Knoxville which is over an hour away and couldn't drive myself. Social Workers at the VA called around.
Most VAMCs have in house vans and shuttle services, so with a mileage radius plus they have contracts with other transport services arranged through the travel office at the hospital. I got a ride from Johnson City Tenn with CPC to Knoxville where I spent a night in a motel. The following morning of surgery, a local DAV van took me to the hospital. If you lived anywhere near me I'd go with you because I've been in your shoes. (When I had family they were never there snyway)
So anyway, most larger cities have senior centers and programs that can offer rides or support, or know of services (apologies, don't know your age), of course the VA Clinics or Hospitals should have Social Workers that know this information. Also reach out to your local American Legion or DAV, many do have vehicles for transport which they also use to take Vets to services for other Vets or community events like Veterans Day parades. I hope this helps, you are not alone, there are many others like us. Good luck with your surgery I'll be thinking of you

If you fall in the categories for various war-times, you can join the American Legion, and they might be able to help. Also, the DAV as suggested. Getting in touch with these organizations can help you find friends, too, who will understand your problems and experiences.