Drug targets for Ebola, Dengue, and Zika viruses found in lab study

This is a wonderful advance in science. These diseases are a scourge for humans.

Thank you for the great medical share sir. Have a great evening.

Thank you my friend LTC (Join to see) that the "scientific journal Cell researchers employed a technique called protein-protein interaction mapping to probe the three viruses: Ebola, Dengue, and Zika. The method uses human cells in laboratory dishes to create a map of each point of contact between viral and human proteins.

"No drugs are currently available to treat Ebola, Dengue, or Zika viruses, which infect millions of people every year and result in severe illness, birth defects, and even death. New research from the Gladstone Institutes and UC San Francisco may finally change that. Scientists identified key ways the three viruses hijack the body's cells, and they found at least one potential drug that can disrupt this process in human cells. What's more, they discovered how the Zika virus might cause microcephaly in infants, the first step in developing a way to stop the disease.

Published in back-to-back papers in the December 13, 2018, issue of the scientific journal Cell, the researchers employed a technique called protein-protein interaction mapping to probe the three viruses. The method uses human cells in laboratory dishes to create a map of each point of contact between viral and human proteins.

The scientists, whose work was conducted under the umbrella of the Host Pathogen Mapping Initiative launched by the Quantitative Biosciences Institute (QBI) at UCSF, are using these comprehensive maps to target the interactions and try to kill the infection.

"We've employed our systematic protein-protein interaction strategy on Ebola, Dengue, and Zika to get a better sense of how these three very problematic viruses hijack, rewire, and infect human cells," said the leader of the two studies Nevan Krogan, PhD, a senior investigator at the Gladstone Institutes, the director of QBI at UCSF, and a professor of cellular and molecular pharmacology at UCSF. "To me, what's most interesting is when we see the same human machinery being hijacked by seemingly very different viruses and different pathogenic proteins."

By comparing one virus's map to another, the researchers can find human proteins that are routinely targeted by several different viruses, and that could potentially be involved in other types of human disease as well."
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